Bubuk Pirazinamid

is a drug primarily used to treat tuberculosis (TB). It is a crystalline powder that is white or off-white in color, somewhat soluble in water, and only sporadically soluble in ethanol or methanol. This product only kills Mycobacterium tuberculosis and has no antibacterial activity against other bacteria. The strength of its anti-tuberculosis effect is closely related to the PH of the environment. When PH=5~5.5, the antibacterial activity is most vigorous; when PH=7, the antibacterial effect is significantly weakened; animal experiments have confirmed that this product can enter cells and has a significant synergistic effect when combined with isoniazid. It is also effective against extracellular tuberculosis bacteria in an acidic environment. There is no cross-resistance between this product and other anti-tuberculosis drugs, and it is easy to develop drug resistance when used alone. The mechanism of action may be that PZA penetrates macrophages containing Mycobacterium tuberculosis and is converted into pyrazinoic acid to exert its antibacterial effect. Depending on the drug concentration and bacterial sensitivity, this product is a nicotinamide derivative with bacteriostatic or bactericidal effects. This product only has antibacterial activity when the PH is acidic.

The structure of this product is similar to nicotinamide, and it can have a bactericidal effect when it enters cells. Under low PH conditions, the antibacterial activity is intense. This product is a first-line anti-tuberculosis drug without cross-resistance with other anti-tuberculosis drugs. It is mainly used for cases in which first-line drug treatment is ineffective. This product can quickly develop drug resistance when used alone and needs to be used in combination with other anti-tuberculosis drugs.

They are combined with other anti-tuberculosis drugs for tuberculosis that have failed to respond to first-line anti-tuberculosis drugs (such as streptomycin, isoniazid, rifampicin, and ethambutol). This product is only effective against mycobacteria. In the past, this product was used as a second-line drug and was often used for retreatment of patients who failed other anti-tuberculosis drugs. Many clinical studies have shown that the short-course treatment plan containing this product is suitable for the initial treatment of phlegm bacteria-positive cases and is generally used for 2 to 3 months. This plan can significantly reduce the re-positive rate of phlegm bacteria after the treatment. This product has been recognized as one of the components of triple or quadruple regimens in short-course chemotherapy.

Xi'an Sonwu Biotech Co. Ltd. has rich experience in the global trade and the health industry. Insisting on faith-based and quality first is our company's principle. We strictly control product quality, which means selection starts from raw material. Besides, we handle every detail and reduce costs to the maximum so our customers can get cost-effective products. Based on these, customers have given much good feedback to our products. So look for Xi'an Sonwu Biotech Co. Ltd. when buying PZA Powder.

It is primarily used for the treatment of tuberculosis (TB). It is an essential component of the standard regimens the World Health Organization (WHO) recommended for drug-sensitive and drug-resistant TB.

When combined with other anti-TB medications, such as isoniazid, rifampicin, and ethambutol, it helps treat active TB infections effectively. It is particularly effective in killing dormant or slow-growing bacteria often present in TB lesions.

1. Conversion to pyrazinoic acid (POA): It is converted to its active form, pyrazinoic acid, by the enzyme pyrazinamidase. This conversion occurs intracellularly in Mycobacterium tuberculosis. POA is thought to disrupt the bacterium's membrane potential and acidification processes, inhibiting its growth and survival.

2. Disruption of fatty acid metabolism: It may interfere with fatty acid synthesis and utilization within the bacterial cell. The disruption may result in the exhaustion of energy reserves, impeding the bacterium's capacity to increase and endure.

3. PH-dependent action: It acts preferentially in an acidic environment, such as found within the phagolysosome of macrophages where M. tuberculosis resides. It is believed that PZA is most effective in this acidic environment, possibly through the protonation of its active form, POA.

4. Synergistic effect: Pyrazinam de has synergized with anti-TB drugs like rifampicin and isoniazid. The combination of these drugs enhances their overall efficacy against M. tuberculosis.

1. Gastrointestinal disturbances: Nausea, vomiting, and loss of appetite are commonly reported side effects. Taking it with food can help reduce these symptoms.

2. Hyperuricemia: It can increase uric acid levels in the blood, which may lead to gout or worsen pre-existing gout symptoms. Individuals with a history of gout should be closely monitored during treatment.

3. Joint pain: Some individuals may experience joint pain or arthritis-like symptoms during it therapy. This side effect is usually reversible upon discontinuation of the medication.

4. Skin reactions: Skin rashes and itching have been reported in some cases. Should a rash or other indications of an allergic reaction appear, such as hives or difficulty breathing, seek medical attention immediately.

5. Hepatotoxicity: It has the potential to cause liver damage. Signs of liver toxicity may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unexplained fatigue. Regular monitoring of liver function is vital during treatment.

6. Central nervous system effects: Rarely, it can cause neurological side effects, including confusion, dizziness, or hallucinations. If you experience any unusual neurological symptoms, consult your healthcare provider.

The usual dosage for adults, combined with other anti-tuberculosis drugs, is 5 to 8.75 mg/kg of body weight every 6 hours, or 6.7 to 11.7 mg/kg every 8 hours, up to 3g per day. When treating isoniazid-resistant bacterial infections, it can be increased to 60 mg/kg daily. Children should not use i unless necessary. When applying them, one should carefully consider the benefits and drawbacks.

① It can also be administered intermittently, 50 mg/kg twice a week. ② When it is used alone to treat tuberculosis, bacteria are prone to develop drug resistance, so it is often used in combination with other anti-tuberculosis drugs. The course of treatment may last 1-2 years, even several years, or indefinitely. ③It is usually not suitable for patients with liver dysfunction unless necessary. People with reduced renal function do not need to reduce the dose when using it. Adults take 30 to 35 mg kg in a single meal per day. For those weighing less than 50 kg, 1.5 g per day; for those weighing over 50 kg, 2 g per day; for those weighing over 75 kg, 2.5 g per day. For children, 20-25 mg/kg per day.

1. Xi'an Sonwu has a factory with sufficient stock. In addition, Xi'an Sonwu has a clean and tidy production department with advanced equipment. Under the company's leadership, researchers continue to develop new products to meet customers' needs.

2. Xi'an Sonwu has advanced t sting equipment and professional testing personnel, all of which show that Xi'an Sonwu aims to provide accurate and effective data and good service.

1. How to inquire?

2. How do you guarantee the quality of products?

3. How do you pack and store NMN?

Pack: Use sealed export-grade drums and vacuum-sealed foil packaging, or pack the goods according to customers' needs.

Storage: For a short time, you can keep it in a dry and cool place and make it avoid sunlight. For a long time, please keep it under 15 degree below zero.

If you want to know the pure pyrazinamide, you can contact Xi'an Sonwu. Click the email, and then you get high-quality

sales@sonwu.com

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